References

A list of journal articles that have used VacciXcell products for various applications.

Drugmand, J., Havelange, N., Osumba, S., Bosco, F., Debras, F., Collignon, F., . . . Castillo, J. (n.d.). New Disposable Fixed-Bed Bioreactor for Cell Culture and Virus Production Based on a Proprietary Agitation and Aeration System. Cells and Culture, 151-155.

(Link: http://link.springer.com/chapter/10.1007/978-90-481-3419-9_24)

 

Drugmand, J., J.-F., J., Agathos, S., & Schneider, Y. (n.d.). Growth of Mammalian and Lepidopteran Cells on BioNOC® II Disks, a Novel Macroporous Microcarrier. Cell Technology for Cell Products, 781-784.

(Link: http://link.springer.com/chapter/10.1007%2F978-1-4020-5476-1_143)

Akiyama, M., Nakayama, D., Takeda, S., Kokame, K., Takagi, J., & Miyata, T. (n.d.). Crystal structure and enzymatic activity of an ADAMTS-13 mutant with the East Asian-specific P475S polymorphism. J Thromb Haemost Journal of Thrombosis and Haemostasis, 1399-1406.

(Link: http://www.ncbi.nlm.nih.gov/pubmed/23621748)

 

Asaoka, Y., Tanaka, T., Tsumoto, K., Tomita, M., & Ide, T. (n.d.). Efficient expression of recombinant soluble human FcγRI in mammalian cells and its characterization. Protein Expression and Purification, 155-161.

(Link: http://www.sciencedirect.com/science/article/pii/S1046592811003524)

 

Brown, A., Mcsharry, J., Adams, J., Kulawy, R., Barnard, R., Newhard, W., . . . Drusano, G. (2011). Pharmacodynamic Analysis of a Serine Protease Inhibitor, MK-4519, against Hepatitis C Virus Using a Novel In Vitro Pharmacodynamic System. Antimicrobial Agents and Chemotherapy, 1170-1181.

(Link: http://www.ncbi.nlm.nih.gov/pubmed/22155837)

 

Chen, Y., Wu, J., Wang, K., Chiang, Y., Lai, C., Chung, Y., & Hu, Y. (n.d.). Baculovirus-mediated production of HDV-like particles in BHK cells using a novel oscillating bioreactor. Journal of Biotechnology, 135-147.

(Link: http://www.ncbi.nlm.nih.gov/pubmed/15951042)

 

Drugmand, J., J.-F., J., Agathos, S., & Schneider, Y. (n.d.). Growth of Mammalian and Lepidopteran Cells on BioNOC® II Disks, a Novel Macroporous Microcarrier. Cell Technology for Cell Products, 781-784.

(Link: http://link.springer.com/chapter/10.1007%2F978-1-4020-5476-1_143)

 

Hammonds, J., Chen, X., Zhang, X., Lee, F., & Spearman, P. (n.d.). Advances in methods for the production, purification, and characterization of HIV-1 Gag–Env pseudovirion vaccines. Vaccine, 8036-8048.

(Link: http://www.ncbi.nlm.nih.gov/pubmed/17936444)

 

Haredy, A., Takenaka, N., Yamada, H., Sakoda, Y., Okamatsu, M., Yamamoto, N., . . . Okamoto, S. (2013). An MDCK Cell Culture-Derived Formalin-Inactivated Influenza Virus Whole-Virion Vaccine from an Influenza Virus Library Confers Cross-Protective Immunity by Intranasal Administration in Mice. Clinical and Vaccine Immunology, 998-1007.

(Link: http://www.ncbi.nlm.nih.gov/pubmed/23637045)

 

Haredy, A., Yamada, H., Sakoda, Y., Okamatsu, M., Yamamoto, N., Omasa, T., . . . Yamanishi, K. (2014). Neuraminidase gene homology contributes to the protective activity of influenza vaccines prepared from the influenza virus library. Journal of General Virology, 2365-2371.

(Link: http://www.ncbi.nlm.nih.gov/pubmed/25053564)

 

Ho, L., Greene, C., Schmidt, A., & Huang, L. (n.d.). Cultivation of HEK 293 cell line and production of a member of the superfamily of G-protein coupled receptors for drug discovery applications using a highly efficient novel bioreactor. Cytotechnology, 117-123.

(Link: http://www.ncbi.nlm.nih.gov/pubmed/19003249)

 

Hu, Y., Lu, J., & Chung, Y. (n.d.). High-density cultivation of insect cells and production of recombinant baculovirus using a novel oscillating bioreactor. Cytotechnology, 145-153.

(Link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3449450/)

 

Huang, K., Lo, W., Chung, Y., Lai, Y., Chen, C., Chou, S., & Hu, Y. (n.d.). Combination of Baculovirus-Mediated Gene Delivery and Packed-Bed Reactor for Scalable Production of Adeno-Associated Virus. Human Gene Therapy, 1161-1170.

(Link: http://www.ncbi.nlm.nih.gov/pubmed/17944574)

 

Jepson, S., Vought, B., Gross, C., Gan, L., Austen, D., Frantz, J., . . . Krauss, R. (2012). LINGO-1, a Transmembrane Signaling Protein, Inhibits Oligodendrocyte Differentiation and Myelination through Intercellular Self-interactions. Journal of Biological Chemistry, 22184-22195.

(Link: http://www.ncbi.nlm.nih.gov/pubmed/22514275)

 

Kato, K., Nishimasu, H., Mihara, E., Ishitani, R., Takagi, J., Aoki, J., & Nureki, O. (2012). Expression, purification, crystallization and preliminary X-ray crystallographic analysis of Enpp1. Acta Cryst Sect F Acta Crystallogr F Struct Biol Cryst Commun Acta Cryst Sect F Struct Biol Cryst Commun Acta Cryst F Struct Biol Cryst Commun Acta Cryst F Acta Crystallographica Section F Structural Biology and Crystallization Communications Acta Crystal, 778-782.

(Link: http://www.ncbi.nlm.nih.gov/pubmed/22750863)

 

Lu, J., Chung, Y., Chan, Z., & Hu, Y. (n.d.). A Novel Oscillating Bioreactor BelloCell: Implications for Insect Cell Culture and Recombinant Protein Production. Biotechnology Letters Biotechnol Lett, 1059-1065.

(Link: http://link.springer.com/article/10.1007%2Fs10529-005-8450-3)

 

Mcsharry, J., Singer, D., Kulawy, R., Brown, A., & Drusano, G. (n.d.). Use of the BelloCell System to Determine the Optimal Dose of Ribavirin to Inhibit the Expression of an HCV Replicon in 2209-23 Cells. Antiviral Research.

(Link: https://www.researchgate.net/publication/247034227_Use_of_the_BelloCell_System_to_Determine_the_Optimal_Dose_of_Ribavirin_to_Inhibit_the_Expression_of_an_HCV_Replicon_in_2209-23_Cells)

 

Tabata, S., Nampo, M., Mihara, E., Tamura-Kawakami, K., Fujii, I., & Takagi, J. (n.d.). A rapid screening method for cell lines producing singly-tagged recombinant proteins using the “TARGET tag” system. Journal of Proteomics, 1777-1785.

(Link: http://www.ncbi.nlm.nih.gov/pubmed/20566373)

 

Toriniwa, H., & Komiya, T. (n.d.). Japanese encephalitis virus production in Vero cells with serum-free medium using a novel oscillating bioreactor. Biologicals, 221-226.

(Link: http://www.ncbi.nlm.nih.gov/pubmed/17400474)

 

Yasui, N., Mihara, E., Nampo, M., Tamura-Kawakami, K., Unno, H., Matsumoto, K., & Takagi, J. (n.d.). Detection of endogenous LRP6 expressed on human cells by monoclonal antibodies specific for the native conformation. Journal of Immunological Methods, 153-160.

(Link: http://www.ncbi.nlm.nih.gov/pubmed/19945460)

VacciXcell has to date sold over 600 CelCradle Single Use Bioreactors and have a growing portfolio of clients. Due to non-disclosure agreements (NDA) only limited information may be provided of our clients.

Some of these clients are:

 

Country Cell Line Virus Strain Cell Density Virus Titer
USA CEF WEE 4 x107 109pfu/ml
Taiwan BHK-21 Pseudorabies 2.35x107 108.8 TCID50/ml
Taiwan HEK-293 Adenovirus 3.5 x107 108pfu/ml
Taiwan SF-9 Baculovirus 6x107 109pfu/ml

Kaiser, P., Werner, M., Jérôme, V., Hübner, H., Buchholz, R., & Freitag, R. (2014). Cell retention by encapsulation for the cultivation of Jurkat cells in fixed and fluidized bed reactors. Biotechnol. Bioeng. Biotechnology and Bioengineering, 2571-2579.

(Link: http://onlinelibrary.wiley.com/doi/10.1002/bit.25304/abstract)

 

Palmer, C., Anzinger, J., Zhou, J., Gouillou, M., Landay, A., Jaworowski, A., . . . Crowe, S. (2014). Glucose Transporter 1-Expressing Proinflammatory Monocytes Are Elevated in Combination Antiretroviral Therapy-Treated and Untreated HIV Subjects. The Journal of Immunology, 5595-5603.

(Link: http://www.ncbi.nlm.nih.gov/pubmed/25367121)

 

Sagare, A., Bell, R., Srivastava, A., Sengillo, J., Singh, I., Nishida, Y., . . . Zlokovic, B. (2013). A Lipoprotein Receptor Cluster IV Mutant Preferentially Binds Amyloid-  and Regulates Its Clearance from the Mouse Brain. Journal of Biological Chemistry, 15154-15166.

(Link: http://www.ncbi.nlm.nih.gov/pubmed/23580652)

 

Roop, J. I., Chang, K. C., & Brem, R. B. (2016). Polygenic evolution of a sugar specialization trade-off in yeast. Nature, 530(7590), 336-339.

(Link: www.nature.com/)