Animal Rabies Vaccine Production

Introduction:

Rabies is a zoonotic disease (a disease that is transmitted from animals to humans), caused by the rabies virus, of the Lyssavirus genus, within the family Rhabdoviridae. Domestic dogs are the most common reservoir of the virus, with more than 99% of human deaths caused by dog-mediated rabies. (Fooksetal.,2017)

The virus is transmitted in the saliva of rabid animals and generally enters the body via infiltration of virus-laden saliva from a rabid animal into a wound (e.g.scratches), or by direct exposure of mucosal surfaces to saliva from an infected animal (e.g.bites). (Centersfordiseasecontrolandprevention,2019)

Canine-mediated human rabies disproportionately affects poor rural communities, particularly children, with the majority (80%) of human deaths occurring in rural areas, where awareness and access to appropriate post-exposure prophylaxis is limited or non-existent. (RabiesGlobalConference,2015)

 

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