Pigs and pork meat constitute more than one-thirds of meat produced worldwide and is an important component of the world economy pertaining to agriculture, trade and global food security. As such, pig health is an important consideration globally. However, infectious diseases pose constraints and challenges to swine production and outbreaks of swine diseases occur commonly - increasingly so with rapid globalization of the pig industry. There are a multitude of swine pathogens and preparedness for an outbreak is imperative. Vaccination of pigs could vastly contribute to enhancing pig health and could impact greatly on improving agricultural economy in swine - producing nations. Vaccines using mammalian cell substrates are an effective solution and need to be produced in a timely manner to handle an epidemic and also for pandemic preparedness.